Prostaglandin E2 and the EP receptors in malignancy: possible therapeutic targets?
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چکیده
منابع مشابه
Prostaglandin E2 and the EP receptors in malignancy: possible therapeutic targets?
Elevated expression of COX-2 and increased levels of PGE2 are found in numerous cancers and are associated with tumour development and progression. Although epidemiological, clinical and preclinical studies have shown that the inhibition of PGE2 synthesis through the use of either non-steroidal anti-inflammatory drugs (NSAIDs) or specific COX-2 inhibitors (COXibs) has the potential to prevent a...
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Prostaglandin E2 (PGE2) is a principal fever mediator that induces hyperthermia when injected into the organum vasculosum lamina terminalis (OVLT) and the adjacent preoptic area of the hypothalamus (POA). PGE (EP) receptors have four subtypes, i.e. EP1, EP2, EP3, and EP4. In the rat OVLT/POA region, at least three of these receptors, i.e. EP1, EP3, and EP4 receptors, have distinctively differen...
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246 words Introduction: 534 words Discussion: 2209 words Abbreviations: COX, cyclooxygenase; COX-2, cyclooxygenase-2; TBS, tris-buffered saline; P-gp, P-glycoprotein; BBB, blood-brain barrier; PGE2, Prostaglandin E2; EEG, Electroencephalogram; NMDA, N-methyl-D-aspartic acid; CNS, central nervous system Section: Neuropharmacology This article has not been copyedited and formatted. The final vers...
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Chronic kidney disease is a leading cause of morbidity and mortality in the world. A better understanding of disease mechanisms has been gained in recent years, but the current management strategies are ineffective at preventing disease progression. A widespread focus of research is placed on elucidating the specific processes implicated to find more effective therapeutic options. PGE2, acting ...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2015
ISSN: 0007-1188
DOI: 10.1111/bph.13331